Evolved from the Brahmi script, Devanagari is used to write Marathi, Hindi, Sanskrit, and Nepali, and remains an important Indic script used in South Asia and beyond. Its technological advances have been slow, and design advances are just starting to pick up. South Asia, and specifically India, has a multilingual cultural landscape, and it is not uncommon for street signs, periodicals, newspapers, and other printed ephemera to typically use two to three languages—English and a regional language or two, or two to three regional languages together. While Indian street signs have long featured beautifully painted, built, or set Devanagari signs, often integrating Latin numbers or words seamlessly, translating this to digital typesetting has not been an equally easy task, owing to the differences in setting the two scripts, the difference in anatomy and reading of the scripts, and the limited availability of Devanagari fonts as compared to Latin. There are also knowledge gaps in multilingual typesetting where a script is often forced to follow Latin typesetting principles. This write-up aims to develop a guide for effectively setting Devanagari alongside Latin type, while honoring the nuances of both scripts.